The association of factor V Leiden mutation (G1691A) with pregnancy complications (miscarriage) in the Iran, East Azerbaijan

Objective: The pathogenesis of human spontaneous abortion involves a complex interaction several genetic and environmental factors. Resistance to anticoagulant activity activated protein C (APC), often due point mutations in Factor V gene. Leiden mutation is definitely associated with pregnancy complications. In this study, we have investigated association factor recurrent miscarriage Iranian patients. Methods: 200 women included study: 100 as patients group 2 or more consecutive unexplained controls at least one childbirth without any Genomic DNA extracted from peripheral blood each person. Presence absence the gene performed by coagulation test, determine homozygous heterozygous mutation, used HRM techniques PCR Kit. Results: Chi-square analysis was significant relationship between mutant G1691A loss, other variables statistical analysis, gestational age family history, statistically loss. Conclusions: results study showed that has an effective role risk complications miscarriage. frequency various countries differences different geographic can prone better management adoption preventive methods.